Title : Polyamine-Conjugated Nitroxides Are Efficacious Inhibitors of Oxidative Reactions Catalyzed by Endothelial-Localized Myeloperoxidase.

Pub. Date : 2021 Jun 21

PMID : 34085520






2 Functional Relationships(s)
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1 Nitroxides effectively inhibited the consumption of MPO"s substrate hydrogen peroxide (H2O2) and formation of HOCl catalyzed by endothelial-localized MPO, with their efficacy dependent on both nitroxide and conjugated-polyamine structure. Hydroxylamine myeloperoxidase Homo sapiens
2 Nitroxides effectively inhibited the consumption of MPO"s substrate hydrogen peroxide (H2O2) and formation of HOCl catalyzed by endothelial-localized MPO, with their efficacy dependent on both nitroxide and conjugated-polyamine structure. Hydroxylamine myeloperoxidase Homo sapiens