Pub. Date : 2021
PMID : 34079457
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present study showed that DEX reduced the production of cleaved caspase1 (CASP1) and destroyed the NLRP3-PYD And CARD Domain Containing (PYCARD)-CASP1 complex assembly, thereby reducing the secretion of IL-1beta interleukin beta (IL-1beta). | Dexmedetomidine | interleukin 1 alpha | Mus musculus |
| 2 | The anti-inflammatory effect of DEX was explored in vivo by detecting NLRP3-CASP1/IL-1beta protein expression and behavioral testing. | Dexmedetomidine | interleukin 1 alpha | Mus musculus |
| 3 | Results: Pre-administration of DEX reduced the protein expression of NLRP3, CASP1, and IL-1beta in the hippocampus of mice induced by surgery and also improved the impairment of learning and memory ability. | Dexmedetomidine | interleukin 1 alpha | Mus musculus |
| 4 | DEX decreased the cleaved CASP1 expression, blocked the assembly of NLRP3-PYCARD-CASP1 complex, and also reduced the secretion of mature IL-1beta in vitro. | Dexmedetomidine | interleukin 1 alpha | Mus musculus |