PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34079457-5	2021	The present study showed that DEX reduced the production of cleaved caspase1 (CASP1) and destroyed the NLRP3-PYD And CARD Domain Containing (PYCARD)-CASP1 complex assembly, thereby reducing the secretion of IL-1beta interleukin beta (IL-1beta).	Dexmedetomidine	30-33	interleukin 1 alpha	Mus musculus	234-242	
34079457-11	2021	The anti-inflammatory effect of DEX was explored in vivo by detecting NLRP3-CASP1/IL-1beta protein expression and behavioral testing.	Dexmedetomidine	32-35	interleukin 1 alpha	Mus musculus	82-90	
34079457-14	2021	Results: Pre-administration of DEX reduced the protein expression of NLRP3, CASP1, and IL-1beta in the hippocampus of mice induced by surgery and also improved the impairment of learning and memory ability.	Dexmedetomidine	31-34	interleukin 1 alpha	Mus musculus	87-95	
34079457-16	2021	DEX decreased the cleaved CASP1 expression, blocked the assembly of NLRP3-PYCARD-CASP1 complex, and also reduced the secretion of mature IL-1beta in vitro.	Dexmedetomidine	0-3	interleukin 1 alpha	Mus musculus	137-145