Title : EGFR phosphorylates HDAC1 to regulate its expression and anti-apoptotic function.

Pub. Date : 2021 May 11

PMID : 33976119






2 Functional Relationships(s)
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1 Specifically, we discover that EGFR activity promotes the tyrosine phosphorylation of HDAC1, which is necessary for its protein stability. Tyrosine epidermal growth factor receptor Homo sapiens
2 Given that HDAC1 overexpression and EGFR activity are strongly related with tumor progression and cancer cell survival, HDAC1 tyrosine phosphorylation may present a possible target to manipulate HDAC1 protein levels in future potential cancer treatment strategies. Tyrosine epidermal growth factor receptor Homo sapiens