Pub. Date : 2021 May 11
PMID : 33976119
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Specifically, we discover that EGFR activity promotes the tyrosine phosphorylation of HDAC1, which is necessary for its protein stability. | Tyrosine | epidermal growth factor receptor | Homo sapiens |
2 | Given that HDAC1 overexpression and EGFR activity are strongly related with tumor progression and cancer cell survival, HDAC1 tyrosine phosphorylation may present a possible target to manipulate HDAC1 protein levels in future potential cancer treatment strategies. | Tyrosine | epidermal growth factor receptor | Homo sapiens |