Title : Sustained IKKβ phosphorylation and NF-κB activation by superoxide-induced peroxynitrite-mediated nitrotyrosine modification of B56γ3 and PP2A inactivation.

Pub. Date : 2021 May

PMID : 33838472






1 Functional Relationships(s)
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1 Through pharmacological or genetic inhibition of SOD1, we show that elevated intracellular superoxide (O2-) mediates sustained IKK phosphorylation, and induces downstream degradation of IkappaBalpha, leading to the nuclear localization and transcriptional activation of NF-kappaB. Superoxides superoxide dismutase 1 Homo sapiens