Protein Name superoxide dismutase 1
Organism Homo sapiens
Gene ID 6647
Gene Symbol


UniProt P00441 (SODC_HUMAN), V9HWC9 (V9HWC9_HUMAN)
Relationships Total Number of functionally related compound(s) : 2118
Total Number of Articles : 3974

superoxide dismutase 1

Gene Summary

The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2020]

  • superoxide dismutase [Cu-Zn]
  • Cu/Zn superoxide dismutase
  • SOD, soluble
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