| Protein Name | superoxide dismutase 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 6647 |
| Gene Symbol | SOD1 |
| UniProt | P00441 (SODC_HUMAN), V9HWC9 (V9HWC9_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
2118
Total Number of Articles : 3974 |
Description |
superoxide dismutase 1 |
| Gene Summary |
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2020] |
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