Title : Hypoxia-Induced Suppression of Antiapoptotic Bcl-2 Expression in Human Bladder Tumor Cells Is Regulated by Caveolin-1-Dependent Adenosine Monophosphate-Activated Protein Kinase Activity.

Pub. Date : 2021 Jun

PMID : 33752282






1 Functional Relationships(s)
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1 The cell growth and Bcl-2 expression level suppressed under hypoxia were reversed with a decrease of the induced Hif-1alpha and Cav-1 levels after AMPK activation with metformin (1 mM) or phenformin (0.1 microM). Metformin BCL2 apoptosis regulator Homo sapiens