Title : Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug-Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach.

Pub. Date : 2021 Feb 17

PMID : 33671323






1 Functional Relationships(s)
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1 The carbamazepine model applies metabolism by CYP3A4 and CYP2C8 to produce carbamazepine-10,11-epoxide, metabolism by CYP2B6 and UDP-glucuronosyltransferase (UGT) 2B7 and glomerular filtration. 10,11-epoxide cytochrome P450 family 2 subfamily C member 8 Homo sapiens