Pub. Date : 2021 Apr
PMID : 33660415
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Neuroprotective effect of ketamine against TNF-alpha-induced necroptosis in hippocampal neurons. | Ketamine | tumor necrosis factor | Mus musculus |
| 2 | The aim of this study was to assess the neuroprotective effect of ketamine against TNF-alpha-induced motor dysfunction and neuronal necroptosis in male C57BL/6J mice in vivo and HT-22 cell lines in vitro. | Ketamine | tumor necrosis factor | Mus musculus |
| 3 | The behavioural testing results of the present study indicate that ketamine ameliorated TNF-alpha-induced neurological dysfunction. | Ketamine | tumor necrosis factor | Mus musculus |
| 4 | Moreover, immunohistochemical staining results showed that TNF-alpha-induced brain dysfunction was caused by necroptosis and microglial activation, which could be attenuated by ketamine pre-treatment inhibiting reactive oxygen species production and mixed lineage kinase domain-like phosphorylation in hippocampal neurons. | Ketamine | tumor necrosis factor | Mus musculus |
| 5 | Therefore, we concluded that ketamine may have neuroprotective effects as a potent inhibitor of necroptosis, which provides a new theoretical and experimental basis for the application of ketamine in TNF-alpha-induced necroptosis-associated diseases. | Ketamine | tumor necrosis factor | Mus musculus |
| 6 | Therefore, we concluded that ketamine may have neuroprotective effects as a potent inhibitor of necroptosis, which provides a new theoretical and experimental basis for the application of ketamine in TNF-alpha-induced necroptosis-associated diseases. | Ketamine | tumor necrosis factor | Mus musculus |