PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33660415-0	2021	Neuroprotective effect of ketamine against TNF-alpha-induced necroptosis in hippocampal neurons.	Ketamine	26-34	tumor necrosis factor	Mus musculus	43-52	
33660415-2	2021	The aim of this study was to assess the neuroprotective effect of ketamine against TNF-alpha-induced motor dysfunction and neuronal necroptosis in male C57BL/6J mice in vivo and HT-22 cell lines in vitro.	Ketamine	66-74	tumor necrosis factor	Mus musculus	83-92	
33660415-3	2021	The behavioural testing results of the present study indicate that ketamine ameliorated TNF-alpha-induced neurological dysfunction.	Ketamine	67-75	tumor necrosis factor	Mus musculus	88-97	
33660415-4	2021	Moreover, immunohistochemical staining results showed that TNF-alpha-induced brain dysfunction was caused by necroptosis and microglial activation, which could be attenuated by ketamine pre-treatment inhibiting reactive oxygen species production and mixed lineage kinase domain-like phosphorylation in hippocampal neurons.	Ketamine	177-185	tumor necrosis factor	Mus musculus	59-68	
33660415-5	2021	Therefore, we concluded that ketamine may have neuroprotective effects as a potent inhibitor of necroptosis, which provides a new theoretical and experimental basis for the application of ketamine in TNF-alpha-induced necroptosis-associated diseases.	Ketamine	29-37	tumor necrosis factor	Mus musculus	200-209	
33660415-5	2021	Therefore, we concluded that ketamine may have neuroprotective effects as a potent inhibitor of necroptosis, which provides a new theoretical and experimental basis for the application of ketamine in TNF-alpha-induced necroptosis-associated diseases.	Ketamine	188-196	tumor necrosis factor	Mus musculus	200-209