Pub. Date : 2021 Apr 1
PMID : 33625942
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin Alleviates Cisplatin-Induced Ototoxicity by Autophagy Induction Possibly via the AMPK/FOXO3a Pathway. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | Notably, metformin activated autophagy and increased the expression levels of the adenosine monophosphate-activated protein kinase (AMPK) and the transcription factor Forkhead box protein O3 (FOXO3a), while cells with AMPK silencing displayed otherwise. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | Notably, metformin activated autophagy and increased the expression levels of the adenosine monophosphate-activated protein kinase (AMPK) and the transcription factor Forkhead box protein O3 (FOXO3a), while cells with AMPK silencing displayed otherwise. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 4 | Notably, metformin activated autophagy and increased the expression levels of the adenosine monophosphate-activated protein kinase (AMPK) and the transcription factor Forkhead box protein O3 (FOXO3a), while cells with AMPK silencing displayed otherwise. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 5 | Our findings indicate that metformin alleviates cisplatin-induced ototoxicity possibly through AMPK/FOXO3a-mediated autophagy machinery. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |