Title : Targeting galectin-3 with a high-affinity antibody for inhibition of high-grade serous ovarian cancer and other MUC16/CA-125-expressing malignancies.

Pub. Date : 2021 Feb 12

PMID : 33580170






2 Functional Relationships(s)
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1 We therefore developed an inhibitory murine monoclonal anti-Gal3 carbohydrate-binding domain antibody, 14D11, which bound human and mouse Gal3 but did not bind human Galectins-1, -7, -8 or -9. Carbohydrates galectin 3 Homo sapiens
2 Competition studies and a docking model suggest that the 14D11 antibody competes with lactose for the carbohydrate binding pocket of Gal3. Carbohydrates galectin 3 Homo sapiens