Pub. Date : 2021 Feb 26
PMID : 33565572
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | HMGB1 regulates ferroptosis through Nrf2 pathway in mesangial cells in response to high glucose. | Glucose | high mobility group box 1 | Homo sapiens |
| 2 | The present study explored the role of high-mobility group box-1 (HMGB1) on the regulation of ferroptosis in mesangial cells in response to high glucose. | Glucose | high mobility group box 1 | Homo sapiens |
| 3 | The present study explored the role of high-mobility group box-1 (HMGB1) on the regulation of ferroptosis in mesangial cells in response to high glucose. | Glucose | high mobility group box 1 | Homo sapiens |
| 4 | Furthermore, nuclear factor E2-related factor 2 (Nrf2) was decreased in DN patients and high glucose mediated translocation of HMGB1 in mesangial cells. | Glucose | high mobility group box 1 | Homo sapiens |
| 5 | Knockdown of HMGB1 suppressed high glucose-induced activation of TLR4/NF-kappaB axis and promoted Nrf2 expression as well as its downstream targets including HO-1, NQO-1, GCLC and GCLM. | Glucose | high mobility group box 1 | Homo sapiens |
| 6 | Collectively, these findings suggest that HMGB1 regulates glucose-induced ferroptosis via Nrf2 pathway in mesangial cells. | Glucose | high mobility group box 1 | Homo sapiens |