PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33565572-0	2021	HMGB1 regulates ferroptosis through Nrf2 pathway in mesangial cells in response to high glucose.	Glucose	88-95	high mobility group box 1	Homo sapiens	0-5	
33565572-2	2021	The present study explored the role of high-mobility group box-1 (HMGB1) on the regulation of ferroptosis in mesangial cells in response to high glucose.	Glucose	145-152	high mobility group box 1	Homo sapiens	39-64	
33565572-2	2021	The present study explored the role of high-mobility group box-1 (HMGB1) on the regulation of ferroptosis in mesangial cells in response to high glucose.	Glucose	145-152	high mobility group box 1	Homo sapiens	66-71	
33565572-6	2021	Furthermore, nuclear factor E2-related factor 2 (Nrf2) was decreased in DN patients and high glucose mediated translocation of HMGB1 in mesangial cells.	Glucose	93-100	high mobility group box 1	Homo sapiens	127-132	
33565572-7	2021	Knockdown of HMGB1 suppressed high glucose-induced activation of TLR4/NF-kappaB axis and promoted Nrf2 expression as well as its downstream targets including HO-1, NQO-1, GCLC and GCLM.	Glucose	35-42	high mobility group box 1	Homo sapiens	13-18	
33565572-8	2021	Collectively, these findings suggest that HMGB1 regulates glucose-induced ferroptosis via Nrf2 pathway in mesangial cells.	Glucose	58-65	high mobility group box 1	Homo sapiens	42-47