Title : A conserved arginine with non-conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors.

Pub. Date : 2021 Apr

PMID : 33506493






1 Functional Relationships(s)
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1 In alpha4beta2 nAChR, the arginine forms a salt-bridge with an aspartate residue in loop B that is necessary for receptor expression, whereas in alpha7 nAChR, this residue is not stabilised by electrostatic interactions, making its side chain highly mobile. Aspartic Acid cholinergic receptor nicotinic alpha 4 subunit Homo sapiens