Protein Name cholinergic receptor nicotinic alpha 4 subunit
Organism Homo sapiens
Gene ID 1137
Gene Symbol


UniProt P43681 (ACHA4_HUMAN), Q4VAQ3 (Q4VAQ3_HUMAN), Q59FV0 (Q59FV0_HUMAN), B4DK78 (B4DK78_HUMAN)
Relationships Total Number of functionally related compound(s) : 760
Total Number of Articles : 1211

cholinergic receptor nicotinic alpha 4 subunit

Gene Summary

This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

  • neuronal acetylcholine receptor subunit alpha-4
  • cholinergic receptor, nicotinic alpha 4
  • cholinergic receptor, nicotinic, alpha 4 (neuronal)
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