Pub. Date : 2021 Mar 5
PMID : 33494625
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BH4 Increases nNOS Activity and Preserves Left Ventricular Function in Diabetes. | sapropterin | nitric oxide synthase 1, neuronal | Mus musculus |
| 2 | Oxidation of the nitric oxide synthase (NOS) co-factor tetrahydrobiopterin (BH4) and dysfunctional NOS activity have been implicated in the pathogenesis of the diabetic vascular and cardiomyopathic phenotype.Objective: Using mice models and human myocardial samples, we evaluated whether and by which mechanism increasing myocardial BH4 availability prevented or reversed LV dysfunction induced by diabetes. | sapropterin | nitric oxide synthase 1, neuronal | Mus musculus |
| 3 | Oxidation of the nitric oxide synthase (NOS) co-factor tetrahydrobiopterin (BH4) and dysfunctional NOS activity have been implicated in the pathogenesis of the diabetic vascular and cardiomyopathic phenotype.Objective: Using mice models and human myocardial samples, we evaluated whether and by which mechanism increasing myocardial BH4 availability prevented or reversed LV dysfunction induced by diabetes. | sapropterin | nitric oxide synthase 1, neuronal | Mus musculus |
| 4 | Oxidation of the nitric oxide synthase (NOS) co-factor tetrahydrobiopterin (BH4) and dysfunctional NOS activity have been implicated in the pathogenesis of the diabetic vascular and cardiomyopathic phenotype.Objective: Using mice models and human myocardial samples, we evaluated whether and by which mechanism increasing myocardial BH4 availability prevented or reversed LV dysfunction induced by diabetes. | sapropterin | nitric oxide synthase 1, neuronal | Mus musculus |
| 5 | The protective effect of BH4 was abolished by CRISPR/Cas9-mediated knockout of neuronal NOS (nNOS) in mGCH1-Tg. | sapropterin | nitric oxide synthase 1, neuronal | Mus musculus |
| 6 | The protective effect of BH4 was abolished by CRISPR/Cas9-mediated knockout of neuronal NOS (nNOS) in mGCH1-Tg. | sapropterin | nitric oxide synthase 1, neuronal | Mus musculus |
| 7 | Conclusions: We uncovered a novel mechanism whereby myocardial BH4 prevents and reverses LV diastolic and systolic dysfunction associated with diabetes via a nNOS-mediated increase in non-insulin dependent myocardial glucose uptake and utilization. | sapropterin | nitric oxide synthase 1, neuronal | Mus musculus |