PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33494625-0	2021	BH4 Increases nNOS Activity and Preserves Left Ventricular Function in Diabetes.	sapropterin	0-3	nitric oxide synthase 1, neuronal	Mus musculus	14-18	
33494625-2	2021	Oxidation of the nitric oxide synthase (NOS) co-factor tetrahydrobiopterin (BH4) and dysfunctional NOS activity have been implicated in the pathogenesis of the diabetic vascular and cardiomyopathic phenotype.Objective: Using mice models and human myocardial samples, we evaluated whether and by which mechanism increasing myocardial BH4 availability prevented or reversed LV dysfunction induced by diabetes.	sapropterin	55-74	nitric oxide synthase 1, neuronal	Mus musculus	17-38	
33494625-2	2021	Oxidation of the nitric oxide synthase (NOS) co-factor tetrahydrobiopterin (BH4) and dysfunctional NOS activity have been implicated in the pathogenesis of the diabetic vascular and cardiomyopathic phenotype.Objective: Using mice models and human myocardial samples, we evaluated whether and by which mechanism increasing myocardial BH4 availability prevented or reversed LV dysfunction induced by diabetes.	sapropterin	76-79	nitric oxide synthase 1, neuronal	Mus musculus	17-38	
33494625-2	2021	Oxidation of the nitric oxide synthase (NOS) co-factor tetrahydrobiopterin (BH4) and dysfunctional NOS activity have been implicated in the pathogenesis of the diabetic vascular and cardiomyopathic phenotype.Objective: Using mice models and human myocardial samples, we evaluated whether and by which mechanism increasing myocardial BH4 availability prevented or reversed LV dysfunction induced by diabetes.	sapropterin	333-336	nitric oxide synthase 1, neuronal	Mus musculus	17-38	
33494625-5	2021	The protective effect of BH4 was abolished by CRISPR/Cas9-mediated knockout of neuronal NOS (nNOS) in mGCH1-Tg.	sapropterin	25-28	nitric oxide synthase 1, neuronal	Mus musculus	79-91	
33494625-5	2021	The protective effect of BH4 was abolished by CRISPR/Cas9-mediated knockout of neuronal NOS (nNOS) in mGCH1-Tg.	sapropterin	25-28	nitric oxide synthase 1, neuronal	Mus musculus	93-97	
33494625-8	2021	Conclusions: We uncovered a novel mechanism whereby myocardial BH4 prevents and reverses LV diastolic and systolic dysfunction associated with diabetes via a nNOS-mediated increase in non-insulin dependent myocardial glucose uptake and utilization.	sapropterin	63-66	nitric oxide synthase 1, neuronal	Mus musculus	158-162