Title : ATP citrate lyase inhibitor triggers endoplasmic reticulum stress to induce hepatocellular carcinoma cell apoptosis via p-eIF2α/ATF4/CHOP axis.

Pub. Date : 2021 Feb

PMID : 33393219






1 Functional Relationships(s)
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1 In conclusion, ACLY might represent a promising target in which BMS-303141 could induce ER stress and activate p-eIF2alpha/ATF4/CHOP axis to promote apoptosis of HCC cells, and synergized with sorafenib to enhance the efficacy of HCC treatment. Sorafenib ATP citrate lyase Homo sapiens