| Protein Name | ATP citrate lyase |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 47 |
| Gene Symbol | ACLY |
| UniProt | P53396 (ACLY_HUMAN), A0A024R1Y2 (A0A024R1Y2_HUMAN), A0A024R1T9 (A0A024R1T9_HUMAN), Q4LE36 (Q4LE36_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
188
Total Number of Articles : 275 |
Description |
ATP citrate lyase |
| Gene Summary |
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014] |
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