Protein Name ATP citrate lyase
Organism Homo sapiens
Gene ID 47
Gene Symbol


UniProt P53396 (ACLY_HUMAN), A0A024R1Y2 (A0A024R1Y2_HUMAN), A0A024R1T9 (A0A024R1T9_HUMAN), Q4LE36 (Q4LE36_HUMAN)
Relationships Total Number of functionally related compound(s) : 188
Total Number of Articles : 275

ATP citrate lyase

Gene Summary

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]

  • ATP-citrate synthase
  • ATP-citrate (pro-S-)-lyase
  • citrate cleavage enzyme
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