Pub. Date : 2020 Dec
PMID : 33252269
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Association of ABCB1 and CYP450 Gene Polymorphisms and their DNA Methylation Status with Steroid-Induced Osteonecrosis of the Femoral Head in the Chinese Population. | Steroids | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | The aim of this study was to investigate the relationship between polymorphisms of the drug-metabolizing enzyme gene, cytochrome P450 (CYP450), and the drug transporter gene, ATP-binding cassette subfamily B member 1 (ABCB1), as well as their DNA methylation status with the pathogenesis of steroid-induced ONFH. | Steroids | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | In the genetic model analysis, the T allele of the rs2032582 locus in the ABCB1 gene was associated with a reduced risk of steroid-induced ONFH under the dominant model (OR = 0.465, 95% CI: 0.223-0.972, p = 0.042). | Steroids | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Conclusions: This study provides evidence for two steroid-induced ONFH susceptibility genes (ABCB1, CYP450) in the Han Chinese population. | Steroids | ATP binding cassette subfamily B member 1 | Homo sapiens |