Title : The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines.

Pub. Date : 2021 Jan 15

PMID : 33249060






1 Functional Relationships(s)
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1 Here, we describe the anti-COVID-19 potential of PTC299, an orally bioavailable compound that is a potent inhibitor of dihydroorotate dehydrogenase (DHODH), the rate-limiting enzyme of the de novo pyrimidine nucleotide biosynthesis pathway. Pyrimidine Nucleotides dihydroorotate dehydrogenase (quinone) Homo sapiens