PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33249060-2 2021 Here, we describe the anti-COVID-19 potential of PTC299, an orally bioavailable compound that is a potent inhibitor of dihydroorotate dehydrogenase (DHODH), the rate-limiting enzyme of the de novo pyrimidine nucleotide biosynthesis pathway. Pyrimidine Nucleotides 197-218 dihydroorotate dehydrogenase (quinone) Homo sapiens 149-154