Title : Design and development of FGF-23 antagonists: Definition of the pharmacophore and initial structure-activity relationships probed by synthetic analogues.

Pub. Date : 2021 Jan 1

PMID : 33232874






2 Functional Relationships(s)
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1 Hereditary hypophosphatemic disorders, TIO, and CKD conditions are believed to be influenced by an excess of Fibroblast Growth Factor-23 (FGF-23) which activates a binary renal FGFRs / alpha-Klotho complex to regulate homeostatic metabolism of phosphate and vitamin D. Phosphates fibroblast growth factor 23 Homo sapiens
2 Hereditary hypophosphatemic disorders, TIO, and CKD conditions are believed to be influenced by an excess of Fibroblast Growth Factor-23 (FGF-23) which activates a binary renal FGFRs / alpha-Klotho complex to regulate homeostatic metabolism of phosphate and vitamin D. Phosphates fibroblast growth factor 23 Homo sapiens