Pub. Date : 2020 Dec
PMID : 33190106
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have previously demonstrated that the Liver X receptor (LXR)-regulated E3 ubiquitin ligase inducible degrader of LDLR (IDOL) is a regulator of cholesterol uptake owing to its ability to promote the ubiquitylation of the low-density lipoprotein receptor (LDLR). | Cholesterol | nuclear receptor subfamily 1, group H, member 3 | Mus musculus |
| 2 | We have previously demonstrated that the Liver X receptor (LXR)-regulated E3 ubiquitin ligase inducible degrader of LDLR (IDOL) is a regulator of cholesterol uptake owing to its ability to promote the ubiquitylation of the low-density lipoprotein receptor (LDLR). | Cholesterol | nuclear receptor subfamily 1, group H, member 3 | Mus musculus |
| 3 | CONCLUSIONS: In conclusion, our study establishes that the LXR-IDOL-LDLR axis is active in the intestine and is part of the molecular circuitry that maintains cholesterol homeostasis in enterocytes. | Cholesterol | nuclear receptor subfamily 1, group H, member 3 | Mus musculus |