Protein Name nuclear receptor subfamily 1, group H, member 3
Organism Mus musculus
Gene ID 22259
Gene Symbol


UniProt Q9Z0Y9 (NR1H3_MOUSE), Q91X41 (Q91X41_MOUSE)
Relationships Total Number of functionally related compound(s) : 362
Total Number of Articles : 733

nuclear receptor subfamily 1, group H, member 3

Gene Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Contributes to transcription cis-regulatory region binding activity. Involved in several processes, including lipid homeostasis; negative regulation of secretion; and regulation of transcription by RNA polymerase II. Acts upstream of or within cellular lipid metabolic process and negative regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including 1st branchial arch; genitourinary system; gut; hemolymphoid system gland; and nervous system. Used to study ovarian hyperstimulation syndrome. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NR1H3 (nuclear receptor subfamily 1 group H member 3). [provided by Alliance of Genome Resources, Apr 2022]

  • oxysterols receptor LXR-alpha
  • LXR alpha
  • liver X receptor alpha
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