Title : Rapamycin Ameliorates Cognitive Impairments and Alzheimer's Disease-Like Pathology with Restoring Mitochondrial Abnormality in the Hippocampus of Streptozotocin-Induced Diabetic Mice.

Pub. Date : 2021 Feb

PMID : 33140268






3 Functional Relationships(s)
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1 Rapamycin, an inhibitor of mTOR, rescued the STZ-induced increases in mTOR/p70S6K activities, tau phosphorylation and Abeta levels, as well as mitochondria abnormality and cognitive impairment in mice. Sirolimus mechanistic target of rapamycin kinase Mus musculus
2 Rapamycin, an inhibitor of mTOR, rescued the STZ-induced increases in mTOR/p70S6K activities, tau phosphorylation and Abeta levels, as well as mitochondria abnormality and cognitive impairment in mice. Sirolimus mechanistic target of rapamycin kinase Mus musculus
3 These findings imply that rapamycin prevents cognitive impairment and protects hippocampus neurons from AD-like pathology and mitochondrial abnormality, and also that rapamycin treatment could normalize these STZ-induced alterations by decreasing hippocampus mTOR/p70S6K hyperactivity. Sirolimus mechanistic target of rapamycin kinase Mus musculus