PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33140268-5 2021 Rapamycin, an inhibitor of mTOR, rescued the STZ-induced increases in mTOR/p70S6K activities, tau phosphorylation and Abeta levels, as well as mitochondria abnormality and cognitive impairment in mice. Sirolimus 0-9 mechanistic target of rapamycin kinase Mus musculus 27-31 33140268-5 2021 Rapamycin, an inhibitor of mTOR, rescued the STZ-induced increases in mTOR/p70S6K activities, tau phosphorylation and Abeta levels, as well as mitochondria abnormality and cognitive impairment in mice. Sirolimus 0-9 mechanistic target of rapamycin kinase Mus musculus 70-74 33140268-6 2021 These findings imply that rapamycin prevents cognitive impairment and protects hippocampus neurons from AD-like pathology and mitochondrial abnormality, and also that rapamycin treatment could normalize these STZ-induced alterations by decreasing hippocampus mTOR/p70S6K hyperactivity. Sirolimus 167-176 mechanistic target of rapamycin kinase Mus musculus 259-263