Title : Zoledronate promotes inflammatory cytokine expression in human CD14-positive monocytes among peripheral mononuclear cells in the presence of γδ T cells.

Pub. Date : 2021 Mar

PMID : 33131052






3 Functional Relationships(s)
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1 While zoledronate induced mRNA expressions of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-6, and interferon-gamma (IFN-gamma) in PBMC, depletion of gammadelta T cells abolished that zoledronate-induced expression of those cytokines, indicating the necessity of gammadelta T cells for expression induction by zoledronate. Zoledronic Acid interleukin 6 Homo sapiens
2 Since it is generally accepted that monocytes and macrophages are primary sources of inflammatory cytokines, CD14+ cells from PBMC were exposed to zoledronate in the presence of PBMC, which resulted in induced expression of mRNAs for IL-1beta, IL-6, and IFN-gamma, but not for TNF-alpha. Zoledronic Acid interleukin 6 Homo sapiens
3 These results indicate that CD14+ cells are responsible, at least in part, for the production of IL-1beta, IL-6, and IFN-gamma in blood exposed to zoledronate. Zoledronic Acid interleukin 6 Homo sapiens