PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33131052-5 2021 While zoledronate induced mRNA expressions of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-6, and interferon-gamma (IFN-gamma) in PBMC, depletion of gammadelta T cells abolished that zoledronate-induced expression of those cytokines, indicating the necessity of gammadelta T cells for expression induction by zoledronate. Zoledronic Acid 6-17 interleukin 6 Homo sapiens 111-115 33131052-7 2021 Since it is generally accepted that monocytes and macrophages are primary sources of inflammatory cytokines, CD14+ cells from PBMC were exposed to zoledronate in the presence of PBMC, which resulted in induced expression of mRNAs for IL-1beta, IL-6, and IFN-gamma, but not for TNF-alpha. Zoledronic Acid 147-158 interleukin 6 Homo sapiens 244-248 33131052-8 2021 These results indicate that CD14+ cells are responsible, at least in part, for the production of IL-1beta, IL-6, and IFN-gamma in blood exposed to zoledronate. Zoledronic Acid 147-158 interleukin 6 Homo sapiens 107-111