Pub. Date : 2020 Nov 1
PMID : 33093270
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AITC induces MRP1 expression by protecting against CS/CSE-mediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis. | allyl isothiocyanate | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | The expression of DJ-1, Nrf2, HO-1, and MRP1 was significantly decreased in the wild type model group, while the expression of each protein was significantly increased after administration of AITC. | allyl isothiocyanate | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | Silencing the expression of DJ-1 in 16HBE cells accelerated CSE-induced protein degradation, and significantly attenuated the AITC-induced mRNA and protein expression of Nrf2 and MRP1. | allyl isothiocyanate | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | The present study describes a novel mechanism by which AITC induces MRP1 expression by protecting against CS/CSEmediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis. | allyl isothiocyanate | NFE2 like bZIP transcription factor 2 | Homo sapiens |