Pub. Date : 2020 Nov 5
PMID : 33027880
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TCDD-induced antagonism of MEHP-mediated migration and invasion partly involves aryl hydrocarbon receptor in MCF7 breast cancer cells. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor | Homo sapiens |
| 2 | Our data suggest that MEHP or TCDD can induce migration and invasion in MCF7 cells, and the promotion is partly AhR dependent. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor | Homo sapiens |
| 3 | We also observed that MEHP antagonized TCDD to reduce AhR-mediated CYP1A1 expression. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor | Homo sapiens |
| 4 | Subsequently, we revealed that MEHP recruited AhR to dioxin response element (DRE) sequences and decreased TCDD-induced AhR-DRE binding in CYP1A1 genes. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor | Homo sapiens |
| 5 | Overall, MEHP is a potential AHR agonist, capable of decreasing TCDD-induced AhR-DRE binding in CYP1A1 genes. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor | Homo sapiens |