Pub. Date : 2021 Feb
PMID : 33003239
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin Promotes Collagen Type I, Keratinocyte Growth Factor-1, and Epidermal Growth Factor Receptor Expressions in the In Vitro Wound Healing Model of Human Gingival Fibroblasts. | Curcumin | epidermal growth factor receptor | Homo sapiens |
| 2 | RESULTS: In unwounded hGFs, curcumin significantly increased KGF-1 and EGFR expressions but not COL1 mRNA expression. | Curcumin | epidermal growth factor receptor | Homo sapiens |
| 3 | Interestingly, curcumin significantly upregulated COL1, KGF-1, and EGFR expressions in the in vitro wound healing model. | Curcumin | epidermal growth factor receptor | Homo sapiens |
| 4 | Furthermore, PD98059 significantly decreased the curcumin-induced COL1 and EGFR expressions, but did not significantly affect KGF-1 upregulation by curcumin. | Curcumin | epidermal growth factor receptor | Homo sapiens |
| 5 | CONCLUSION: Curcumin induced KGF-1 and EGFR expressions in unwounded hGFs. | Curcumin | epidermal growth factor receptor | Homo sapiens |
| 6 | In the in vitro wound healing model, curcumin upregulated COL1 and EGFR expression via the ERK pathway and increased KGF-1 expression, possibly by an ERK-independent mechanism. | Curcumin | epidermal growth factor receptor | Homo sapiens |