Title : Asenapine and iloperidone decrease the expression of major cytochrome P450 enzymes CYP1A2 and CYP3A4 in human hepatocytes. A significance for drug-drug interactions during combined therapy.

Pub. Date : 2020 Nov 1

PMID : 32941854






1 Functional Relationships(s)
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1 CYP activities were measured in the incubation medium using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A1/2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19) and testosterone 6beta-hydroxylation (CYP3A4). Diclofenac cytochrome P450 family 4 subfamily F member 3 Homo sapiens