Protein Name cytochrome P450 family 4 subfamily F member 3
Organism Homo sapiens
Gene ID 4051
Gene Symbol


UniProt Q08477 (CP4F3_HUMAN), A0A024R7J8 (A0A024R7J8_HUMAN), A0A024R7I2 (A0A024R7I2_HUMAN)
Relationships Total Number of functionally related compound(s) : 2473
Total Number of Articles : 3355

cytochrome P450 family 4 subfamily F member 3

Gene Summary

This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2019]

  • cytochrome P450 4F3
  • 20-HETE synthase
  • 20-hydroxyeicosatetraenoic acid synthase
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