Title : Pioglitazone alleviates cisplatin nephrotoxicity by suppressing mitochondria-mediated apoptosis via SIRT1/p53 signalling.

Pub. Date : 2020 Oct

PMID : 32881246






2 Functional Relationships(s)
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1 Apoptosis is associated with mitochondrial dysfunction and SIRT1 activation can decrease cell apoptosis in cisplatin nephrotoxicity. Cisplatin sirtuin 1 Homo sapiens
2 These results implied PIO attenuated cisplatin nephrotoxicity by suppressing mitochondria-mediated apoptosis through regulating SIRT1/p53 signalling. Cisplatin sirtuin 1 Homo sapiens