Pub. Date : 2020 Oct
PMID : 32863909
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GLI1 activation is a key mechanism of erlotinib resistance in human non-small cell lung cancer. | Erlotinib Hydrochloride | GLI family zinc finger 1 | Homo sapiens |
| 2 | In the present study, the role of GLI1 in erlotinib resistance was investigated. | Erlotinib Hydrochloride | GLI family zinc finger 1 | Homo sapiens |
| 3 | GLI1 mRNA expression levels were found to be positively correlated with the IC50 of erlotinib in 15 non-small cell lung cancer (NSCLC) cell lines. | Erlotinib Hydrochloride | GLI family zinc finger 1 | Homo sapiens |
| 4 | The downregulation of GLI1 using siRNA sensitized lung cancer cells to the erlotinib treatment, whereas the overexpression of GLI1 increased the survival of lung cancer cells in the presence of erlotinib, indicating that Hh/GLI activation may play a critical role in the development of TKI resistance in lung cancer. | Erlotinib Hydrochloride | GLI family zinc finger 1 | Homo sapiens |
| 5 | The downregulation of GLI1 using siRNA sensitized lung cancer cells to the erlotinib treatment, whereas the overexpression of GLI1 increased the survival of lung cancer cells in the presence of erlotinib, indicating that Hh/GLI activation may play a critical role in the development of TKI resistance in lung cancer. | Erlotinib Hydrochloride | GLI family zinc finger 1 | Homo sapiens |
| 6 | Combined treatment with erlotinib and a GLI1 inhibitor reduced the cell viability synergistically. | Erlotinib Hydrochloride | GLI family zinc finger 1 | Homo sapiens |
| 7 | A retrospective study of patients with NSCLC treated with erlotinib revealed that those with a high IHC score for GLI1 protein expression had a poorer prognosis. | Erlotinib Hydrochloride | GLI family zinc finger 1 | Homo sapiens |