Protein Name GLI family zinc finger 1
Organism Homo sapiens
Gene ID 2735
Gene Symbol

GLI1

UniProt P08151 (GLI1_HUMAN), B4DNF7 (B4DNF7_HUMAN)
Relationships Total Number of functionally related compound(s) : 334
Total Number of Articles : 511
Description

GLI family zinc finger 1

Gene Summary

This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

synonyms
  • zinc finger protein GLI1
  • GLI-Kruppel family member GLI1
  • glioma-associated oncogene 1
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Properties