Pub. Date : 2020 Oct 15
PMID : 32800810
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Amisulpride alleviates chronic mild stress-induced cognitive deficits: Role of prefrontal cortex microglia and Wnt/beta-catenin pathway. | Amisulpride | catenin beta 1 | Rattus norvegicus |
| 2 | Hitherto, the direct effects of amisulpride on Wnt/beta-catenin signaling and microglial activity have not been thoroughly studied. | Amisulpride | catenin beta 1 | Rattus norvegicus |
| 3 | This study aimed at investigating the effects of chronic amisulpride treatment on Wnt/beta-catenin signaling and pro-inflammatory microglial activation and its role in alleviation of depressive-like behavior and cognitive deficits elicited by unpredictable chronic mild stress (UCMS). | Amisulpride | catenin beta 1 | Rattus norvegicus |
| 4 | Amisulpride improved UCMS-induced behavioral/cognitive deficits, ameliorated Wnt/beta-catenin signaling dysregulation and pro-inflammatory microglial activation. | Amisulpride | catenin beta 1 | Rattus norvegicus |
| 5 | This work highlights the antidepressant and pro-cognitive effects of amisulpride in UCMS-exposed rats that could be mediated by modulation of Wnt/beta-catenin pathway activity and amelioration of pro-inflammatory microglial activation in the prefrontal cortex. | Amisulpride | catenin beta 1 | Rattus norvegicus |