Pub. Date : 2020 Aug 12
PMID : 32787917
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway. | Atorvastatin | nitric oxide synthase 3 | Rattus norvegicus |
| 2 | The role of miRNAs and AKT/eNOS signaling pathway in the promoted angiogenesis of ATV-Exos were assessed with their inhibitors. | Atorvastatin | nitric oxide synthase 3 | Rattus norvegicus |
| 3 | And AKT/eNOS pathway was activated by ATV-Exos and the pro-angiogenic effects of ATV-Exo were attenuated after the pathway being blocked. | Atorvastatin | nitric oxide synthase 3 | Rattus norvegicus |
| 4 | And AKT/eNOS pathway was activated by ATV-Exos and the pro-angiogenic effects of ATV-Exo were attenuated after the pathway being blocked. | Atorvastatin | nitric oxide synthase 3 | Rattus norvegicus |
| 5 | CONCLUSIONS: Exosomes originated from ATV-pretreated MSCs might serve as a potential strategy for the treatment of diabetic skin defects through enhancing the biological function of endothelial cells via AKT/eNOS pathway by upregulating the miR-221-3p. | Atorvastatin | nitric oxide synthase 3 | Rattus norvegicus |