Pub. Date : 2020 Aug
PMID : 32765665
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ginsenoside Rg1 protects against Sca-1+ HSC/HPC cell aging by regulating the SIRT1-FOXO3 and SIRT3-SOD2 signaling pathways in a gamma-ray irradiation-induced aging mice model. | ginsenoside Rg1 | lymphocyte antigen 6 complex, locus A | Mus musculus |
| 2 | However, Rg1 significantly attenuated the senescence of Sca-1+ HSC/HPCs in the gamma-ray irradiation aging mice model. | ginsenoside Rg1 | lymphocyte antigen 6 complex, locus A | Mus musculus |
| 3 | The percentage of Sca-1+ HSC/HPCs arrested at the G1 phase in the Rg1 group was significantly decreased compared with that in the gamma-ray irradiation group (P<0.05). | ginsenoside Rg1 | lymphocyte antigen 6 complex, locus A | Mus musculus |
| 4 | In conclusion, the present study indicates that Rg1 exerts anti-aging effects via the regulation of SIRT1-FOXO3 and SIRT3-SOD2 signaling pathways, and triggering the progression of Sca-1+ HSC/HPCs from the G1 phase to the S phase in gamma-ray irradiation-induced aging mice. | ginsenoside Rg1 | lymphocyte antigen 6 complex, locus A | Mus musculus |