Pub. Date : 2020
PMID : 32714568
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Depletion of the anti-apoptotic protein FLIP, which we identify as a novel mediator of resistance to MLN4924, enhanced apoptosis in a p53-, TRAIL-R2/DR5-, and caspase-8-dependent manner. | pevonedistat | TNF receptor superfamily member 10b | Homo sapiens |
| 2 | Depletion of the anti-apoptotic protein FLIP, which we identify as a novel mediator of resistance to MLN4924, enhanced apoptosis in a p53-, TRAIL-R2/DR5-, and caspase-8-dependent manner. | pevonedistat | TNF receptor superfamily member 10b | Homo sapiens |
| 3 | Notably, TRAIL-R2 was involved in potentiating the apoptotic response to MLN4924 in the absence of FLIP, in a ligand-independent manner. | pevonedistat | TNF receptor superfamily member 10b | Homo sapiens |