CPRiL

Protein Name	TNF receptor superfamily member 10b
Organism	Homo sapiens
Gene ID	8795
Gene Symbol	TNFRSF10B
UniProt	O14763 (TR10B_HUMAN), Q7Z2I8 (Q7Z2I8_HUMAN)
Relationships	Total Number of functionally related compound(s) : 608 Total Number of Articles : 840
Description	TNF receptor superfamily member 10b
Gene Summary	The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
synonyms	tumor necrosis factor receptor superfamily member 10B Fas-like protein TNF-related apoptosis-inducing ligand receptor 2 apoptosis inducing protein TRICK2A/2B apoptosis inducing receptor TRAIL-R2 cytotoxic TRAIL receptor-2 death domain containing receptor for TRAIL/Apo-2L death receptor 5 p53-regulated DNA damage-inducible cell death receptor(killer) tumor necrosis factor receptor superfamily, member 10b tumor necrosis factor receptor-like protein ZTNFR9 CD262 DR5 KILLER KILLER/DR5 TRAIL-R2 TRAILR2 TRICK2 TRICK2A TRICK2B TRICKB ZTNFR9 Click to show/hide the synonyms
Properties