Pub. Date : 2020 Nov
PMID : 32690540
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanistically, BBOX1 binds with the calcium channel inositol-1,4,5-trisphosphate receptor type 3 (IP3R3) in an enzymatic-dependent manner and prevents its ubiquitination and proteasomal degradation. | Calcium | inositol 1,4,5-trisphosphate receptor type 3 | Homo sapiens |
| 2 | BBOX1 depletion suppresses IP3R3 mediated endoplasmic reticulum calcium release, therefore impairing calcium-dependent energy-generating processes including mitochondrial respiration and mTORC1 mediated glycolysis, which leads to apoptosis and impaired cell cycle progression in TNBC cells. | Calcium | inositol 1,4,5-trisphosphate receptor type 3 | Homo sapiens |
| 3 | BBOX1 depletion suppresses IP3R3 mediated endoplasmic reticulum calcium release, therefore impairing calcium-dependent energy-generating processes including mitochondrial respiration and mTORC1 mediated glycolysis, which leads to apoptosis and impaired cell cycle progression in TNBC cells. | Calcium | inositol 1,4,5-trisphosphate receptor type 3 | Homo sapiens |
| 4 | Our study highlights the importance of targeting previously uncharacterized BBOX1-IP3R3-calcium oncogenic signaling axis in TNBC. | Calcium | inositol 1,4,5-trisphosphate receptor type 3 | Homo sapiens |