PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32690540-5 2020 Mechanistically, BBOX1 binds with the calcium channel inositol-1,4,5-trisphosphate receptor type 3 (IP3R3) in an enzymatic-dependent manner and prevents its ubiquitination and proteasomal degradation. Calcium 38-45 inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens 100-105 32690540-6 2020 BBOX1 depletion suppresses IP3R3 mediated endoplasmic reticulum calcium release, therefore impairing calcium-dependent energy-generating processes including mitochondrial respiration and mTORC1 mediated glycolysis, which leads to apoptosis and impaired cell cycle progression in TNBC cells. Calcium 64-71 inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens 27-32 32690540-6 2020 BBOX1 depletion suppresses IP3R3 mediated endoplasmic reticulum calcium release, therefore impairing calcium-dependent energy-generating processes including mitochondrial respiration and mTORC1 mediated glycolysis, which leads to apoptosis and impaired cell cycle progression in TNBC cells. Calcium 101-108 inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens 27-32 32690540-8 2020 Our study highlights the importance of targeting previously uncharacterized BBOX1-IP3R3-calcium oncogenic signaling axis in TNBC. Calcium 88-95 inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens 82-87