PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32655375-0 2020 CB1 Cannabinoid Receptors Stimulate Gbetagamma-GRK2-Mediated FAK Phosphorylation at Tyrosine 925 to Regulate ERK Activation Involving Neuronal Focal Adhesions. Tyrosine 84-92 protein tyrosine kinase 2 Homo sapiens 61-64 32655375-3 2020 Here, immunoblotting analyses using antibodies against FAK phospho-Tyr 925 and ERK2 phospho-Tyr 204 demonstrated CB1-stimulated FAK 925 Tyr-P and ERK2 204 Tyr-P (0-5 min) which was followed by a decline in Tyr-P (5-20 min). Tyrosine 67-70 protein tyrosine kinase 2 Homo sapiens 55-58 32655375-3 2020 Here, immunoblotting analyses using antibodies against FAK phospho-Tyr 925 and ERK2 phospho-Tyr 204 demonstrated CB1-stimulated FAK 925 Tyr-P and ERK2 204 Tyr-P (0-5 min) which was followed by a decline in Tyr-P (5-20 min). Tyrosine 67-70 protein tyrosine kinase 2 Homo sapiens 128-131 32655375-3 2020 Here, immunoblotting analyses using antibodies against FAK phospho-Tyr 925 and ERK2 phospho-Tyr 204 demonstrated CB1-stimulated FAK 925 Tyr-P and ERK2 204 Tyr-P (0-5 min) which was followed by a decline in Tyr-P (5-20 min). Tyrosine 92-95 protein tyrosine kinase 2 Homo sapiens 55-58 32655375-3 2020 Here, immunoblotting analyses using antibodies against FAK phospho-Tyr 925 and ERK2 phospho-Tyr 204 demonstrated CB1-stimulated FAK 925 Tyr-P and ERK2 204 Tyr-P (0-5 min) which was followed by a decline in Tyr-P (5-20 min). Tyrosine 92-95 protein tyrosine kinase 2 Homo sapiens 128-131 32655375-3 2020 Here, immunoblotting analyses using antibodies against FAK phospho-Tyr 925 and ERK2 phospho-Tyr 204 demonstrated CB1-stimulated FAK 925 Tyr-P and ERK2 204 Tyr-P (0-5 min) which was followed by a decline in Tyr-P (5-20 min). Tyrosine 92-95 protein tyrosine kinase 2 Homo sapiens 55-58 32655375-3 2020 Here, immunoblotting analyses using antibodies against FAK phospho-Tyr 925 and ERK2 phospho-Tyr 204 demonstrated CB1-stimulated FAK 925 Tyr-P and ERK2 204 Tyr-P (0-5 min) which was followed by a decline in Tyr-P (5-20 min). Tyrosine 92-95 protein tyrosine kinase 2 Homo sapiens 128-131 32655375-5 2020 The FAK inhibitors Y11 and PF 573228 abolished FAK 925 Tyr-P and partially inhibited ERK2 204 Tyr-P. FAK 925 Tyr-P and ERK2 204 Tyr-P were adhesion-dependent, required an intact actin cytoskeleton, and were mediated by integrins, Flk-1 vascular endothelial growth factor receptors, and epidermal growth factor receptors. Tyrosine 55-58 protein tyrosine kinase 2 Homo sapiens 4-7 32655375-5 2020 The FAK inhibitors Y11 and PF 573228 abolished FAK 925 Tyr-P and partially inhibited ERK2 204 Tyr-P. FAK 925 Tyr-P and ERK2 204 Tyr-P were adhesion-dependent, required an intact actin cytoskeleton, and were mediated by integrins, Flk-1 vascular endothelial growth factor receptors, and epidermal growth factor receptors. Tyrosine 55-58 protein tyrosine kinase 2 Homo sapiens 47-50 32655375-5 2020 The FAK inhibitors Y11 and PF 573228 abolished FAK 925 Tyr-P and partially inhibited ERK2 204 Tyr-P. FAK 925 Tyr-P and ERK2 204 Tyr-P were adhesion-dependent, required an intact actin cytoskeleton, and were mediated by integrins, Flk-1 vascular endothelial growth factor receptors, and epidermal growth factor receptors. Tyrosine 55-58 protein tyrosine kinase 2 Homo sapiens 47-50 32655375-5 2020 The FAK inhibitors Y11 and PF 573228 abolished FAK 925 Tyr-P and partially inhibited ERK2 204 Tyr-P. FAK 925 Tyr-P and ERK2 204 Tyr-P were adhesion-dependent, required an intact actin cytoskeleton, and were mediated by integrins, Flk-1 vascular endothelial growth factor receptors, and epidermal growth factor receptors. Tyrosine 94-97 protein tyrosine kinase 2 Homo sapiens 4-7 32655375-5 2020 The FAK inhibitors Y11 and PF 573228 abolished FAK 925 Tyr-P and partially inhibited ERK2 204 Tyr-P. FAK 925 Tyr-P and ERK2 204 Tyr-P were adhesion-dependent, required an intact actin cytoskeleton, and were mediated by integrins, Flk-1 vascular endothelial growth factor receptors, and epidermal growth factor receptors. Tyrosine 94-97 protein tyrosine kinase 2 Homo sapiens 4-7 32655375-5 2020 The FAK inhibitors Y11 and PF 573228 abolished FAK 925 Tyr-P and partially inhibited ERK2 204 Tyr-P. FAK 925 Tyr-P and ERK2 204 Tyr-P were adhesion-dependent, required an intact actin cytoskeleton, and were mediated by integrins, Flk-1 vascular endothelial growth factor receptors, and epidermal growth factor receptors. Tyrosine 94-97 protein tyrosine kinase 2 Homo sapiens 4-7 32655375-6 2020 FAK 925 Tyr-P and ERK2 204 Tyr-P were blocked by the Gbetagamma inhibitor gallein, a GRK2 inhibitor, and GRK2 siRNA silencing, suggesting Gbetagamma and GRK2 participate in FAK-mediated ERK2 activation. Tyrosine 8-11 protein tyrosine kinase 2 Homo sapiens 0-3 32655375-6 2020 FAK 925 Tyr-P and ERK2 204 Tyr-P were blocked by the Gbetagamma inhibitor gallein, a GRK2 inhibitor, and GRK2 siRNA silencing, suggesting Gbetagamma and GRK2 participate in FAK-mediated ERK2 activation. Tyrosine 8-12 protein tyrosine kinase 2 Homo sapiens 0-3 32655375-7 2020 Together, these studies indicate FAK 925 Tyr-P occurs concurrently with CB1-stimulated ERK2 activation and requires the actin cytoskeleton and Gi/obetagamma-GRK2-mediated cross-talk between CB1, integrins, and receptor tyrosine kinases (RTKs). Tyrosine 41-44 protein tyrosine kinase 2 Homo sapiens 33-36