Pub. Date : 2021 Aug
PMID : 32593591
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pim1 kinase provides protection against high glucose-induced stress and apoptosis in cultured dorsal root ganglion neurons. | Glucose | Pim-1 proto-oncogene, serine/threonine kinase | Homo sapiens |
| 2 | Hyperglycemia causes compensatory upregulation of Pim1 kinase in the DRG neurons, which provides protection against high glucose-induced oxidative stress and ER stress. | Glucose | Pim-1 proto-oncogene, serine/threonine kinase | Homo sapiens |
| 3 | Pharmacological inhibition of Pim1 not only sensitizes the stress response to high glucose in the DRG neurons, but also accelerates the apoptosis of DRG neurons in vitro. | Glucose | Pim-1 proto-oncogene, serine/threonine kinase | Homo sapiens |
| 4 | Therefore, our work provides experimental evidence for the prevention of high glucose-induced neuronal stress and apoptosis by targeting Pim1 kinase. | Glucose | Pim-1 proto-oncogene, serine/threonine kinase | Homo sapiens |