Pub. Date : 2020 Sep
PMID : 32582992
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Significant changes in the E2F1/Cdc25a/Cdk2 pathway in the RB cells were detected by RNA-seq following carboplatin or lobaplatin intervention. | Carboplatin | E2F transcription factor 1 L homeolog | Xenopus laevis |
| 2 | RT-qPCR, immunofluorescence and immunohistochemical analyses in vivo and in vitro demonstrated that the trends of drug-induced inhibition of tumor pathological changes may have been regulated through the E2F1/Cdc25a/Cdk2 pathway, and that lobaplatin was more effective than carboplatin in controlling tumors in vivo. | Carboplatin | E2F transcription factor 1 L homeolog | Xenopus laevis |