Pub. Date : 2020 May 14
PMID : 32476787
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARalpha. | Folic Acid | peroxisome proliferator activated receptor alpha | Rattus norvegicus |
| 2 | Furthermore, peroxisome proliferator-activated receptor alpha (PPARalpha) and silence information regulation factor 1 (SIRT1) were restored by folic acid in HFD-fed rats and palmitic acid-exposed Huh7 cell line. | Folic Acid | peroxisome proliferator activated receptor alpha | Rattus norvegicus |
| 3 | Furthermore, peroxisome proliferator-activated receptor alpha (PPARalpha) and silence information regulation factor 1 (SIRT1) were restored by folic acid in HFD-fed rats and palmitic acid-exposed Huh7 cell line. | Folic Acid | peroxisome proliferator activated receptor alpha | Rattus norvegicus |
| 4 | CONCLUSION: Folic acid improves hepatic lipid metabolism by upregulating PPARalpha levels via a SIRT1-dependent mechanism and restores hepatic one-carbon metabolism and diversity of gut microbiota, thereby attenuating HFD-induced NASH in rats. | Folic Acid | peroxisome proliferator activated receptor alpha | Rattus norvegicus |