Protein Name peroxisome proliferator activated receptor alpha
Organism Rattus norvegicus
Gene ID 25747
Gene Symbol


UniProt P37230 (PPARA_RAT)
Relationships Total Number of functionally related compound(s) : 748
Total Number of Articles : 1276

peroxisome proliferator activated receptor alpha

Gene Summary

Enables several functions, including MDM2/MDM4 family protein binding activity; NFAT protein binding activity; and nuclear receptor activity. Involved in several processes, including behavioral response to nicotine; negative regulation of cell growth involved in cardiac muscle cell development; and response to ethanol. Located in nucleus. Used to study hepatocellular carcinoma; hypertension; hypertensive encephalopathy; and periodontitis. Biomarker of alcoholic hepatitis; fatty liver disease; hydrocephalus; and hypertension. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

  • peroxisome proliferator-activated receptor alpha
  • PPAR-alpha
  • nuclear receptor subfamily 1 group C member 1
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