| Protein Name | peroxisome proliferator activated receptor alpha |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 25747 |
| Gene Symbol | Ppara |
| UniProt | P37230 (PPARA_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
748
Total Number of Articles : 1276 |
Description |
peroxisome proliferator activated receptor alpha |
| Gene Summary |
Enables several functions, including MDM2/MDM4 family protein binding activity; NFAT protein binding activity; and enzyme binding activity. Involved in several processes, including behavioral response to nicotine; cellular response to fructose stimulus; and negative regulation of cell growth involved in cardiac muscle cell development. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Used to study hepatocellular carcinoma; hypertension; hypertensive encephalopathy; and periodontitis. Biomarker of alcoholic hepatitis; hydrocephalus; hypertension; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Jul 2025] |
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